Toscana virus in Spain

Toscana virus (TOSV, Phlebovirus, family Bunyaviridae) infection is one of the most prevalent arboviruses in Spain. Within the objectives of a multidisciplinary network, a study on the epidemiology of TOSV was conducted in Granada, in southern Spain. The overall seroprevalence rate was 24.9%, signif...

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Bibliographic Details
Published in:Emerging infectious diseases 2005-11, Vol.11 (11), p.1701-1707
Main Authors: Sanbonmatsu-Gámez, Sara, Pérez-Ruiz, Mercedes, Collao, Ximena, Sánchez-Seco, María Paz, Morillas-Márquez, Francisco, de la Rosa-Fraile, Manuel, Navarro-Mari, José Maria, Tenorio, Antonio
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - blood
Arbovirus diseases
Bunyaviridae
Development and progression
Diagnosis
Female
Humans
Immunoglobulin G - blood
Insect Vectors - virology
Male
Phlebotomus - virology
Phlebotomus Fever - epidemiology
Phlebotomus Fever - virology
Phlebovirus
Phylogeny
Prevalence
Sandfly fever Naples virus - classification
Sandfly fever Naples virus - genetics
Sandfly fever Naples virus - immunology
Sandfly fever Naples virus - isolation & purification
Sequence Analysis, DNA
seroprevalence
Spain
Spain - epidemiology
Toscana virus
vectors
Viral Proteins - chemistry
Viral Proteins - genetics
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Summary:Toscana virus (TOSV, Phlebovirus, family Bunyaviridae) infection is one of the most prevalent arboviruses in Spain. Within the objectives of a multidisciplinary network, a study on the epidemiology of TOSV was conducted in Granada, in southern Spain. The overall seroprevalence rate was 24.9%, significantly increasing with age. TOSV was detected in 3 of 103 sandfly pools by viral culture or reverse transcription-polymerase chain reaction from a region of the L gene. Nucleotide sequence homology was 99%-100% in TOSV from vectors and patients and 80%-81% compared to the Italian strain ISS Phl.3. Sequencing of the N gene of TOSV isolates from patients and vectors indicated 87%-88% and 100% homology at the nucleotide and amino acid levels, respectively, compared to the Italian strain. These findings demonstrate the circulation of at least 2 different lineages of TOSV in the Mediterranean basin, the Italian lineage and the Spanish lineage.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1111.050851