Loading…

Prospects for using risk scores in polygenic medicine

Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of co...

Full description

Saved in:
Bibliographic Details
Published in:Genome medicine 2017-11, Vol.9 (1), p.96-96, Article 96
Main Authors: Lewis, Cathryn M, Vassos, Evangelos
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use.
ISSN:1756-994X
1756-994X
DOI:10.1186/s13073-017-0489-y