Association between very advanced maternal age women with gestational diabetes mellitus and the risks of adverse infant outcomes: a cohort study from the NVSS 2014-2019

To evaluate the association between gestational diabetes mellitus (GDM) and infant outcomes in women of very advanced maternal age (vAMA) (≥45 years). This cohort study utilized data from the National Vital Statistics System (NVSS) database (2014-2019) in the United States. Preterm birth was the pri...

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Bibliographic Details
Published in:BMC pregnancy and childbirth 2023-03, Vol.23 (1), p.158-158, Article 158
Main Authors: Lu, Lin, He, Lidan, Hu, Jifen, Li, Jianhua
Format: Article
Language:English
Subjects:
Birth Weight
Cohort analysis
Cohort Studies
Diabetes, Gestational - therapy
Female
Fetal Growth Retardation
Gestational diabetes
Gestational diabetes mellitus
Humans
Infant
Infant outcomes
Infant, Newborn
Infertility
Maternal Age
Middle Aged
Nutrition
NVSS
Pregnancy
Pregnancy Outcome
Premature Birth
Very advanced maternal age
Womens health
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Summary:To evaluate the association between gestational diabetes mellitus (GDM) and infant outcomes in women of very advanced maternal age (vAMA) (≥45 years). This cohort study utilized data from the National Vital Statistics System (NVSS) database (2014-2019) in the United States. Preterm birth was the primary outcome, which was subdivided into extremely preterm, very preterm, and moderate or late preterm. The secondary outcomes were neonatal intensive care unit (NICU) admission, low birthweight and small for gestational age. Univariate and multivariate logistic regression analyses were used to explore the association between GDM and infant outcomes among vAMA women. Subgroup analyses were performed based on race and use of infertility treatment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. A total of 52,544 vAMA pregnant women were included. All analysis made comparisons between women with vAMA and GDM and women with vAMA and no GDM. Women with GDM had a significantly higher risk of preterm birth than those without GDM (OR = 1.26, 95%CI = 1.18-1.36, P 
ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-023-05449-0