IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis

Sepsis is a high-incidence disease and demands intensive care. Finding effective treatment is the key to cure sepsis. Studies have shown a lower level of vitamin C in patients with sepsis. Therefore, vitamin C supplementation has become one of the measures to treat sepsis. However, the clinical stud...

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Bibliographic Details
Published in:International journal of clinical practice (Esher) 2023, Vol.2023, p.6733465-15
Main Authors: Wen, Chengli, Li, Yuan, Hu, Qinxue, Liu, Hui, Xu, Xinxin, Lü, Muhan
Format: Article
Language:English
Subjects:
Ascorbic acid
Ascorbic Acid - therapeutic use
Dietary supplements
Health care expenditures
Hospitals
Humans
Medical research
Meta-analysis
Mortality
Multicenter Studies as Topic
Patients
Risk assessment
Sepsis
Sepsis - drug therapy
Systematic review
Ventilators
Vitamin C
Vitamins - therapeutic use
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Summary:Sepsis is a high-incidence disease and demands intensive care. Finding effective treatment is the key to cure sepsis. Studies have shown a lower level of vitamin C in patients with sepsis. Therefore, vitamin C supplementation has become one of the measures to treat sepsis. However, the clinical studies of vitamin C in the treatment of sepsis have been controversial. We performed a meta-analysis to evaluate vitamin C’s efficacy and safety in the treatment of sepsis. We searched four electronic databases: PubMed, Embase, Web of Science, and the Cochrane Library, and two researchers independently screened 24 eligible RCTs published in English. Our review demonstrates that intravenous (IV) vitamin C might improve short-term mortality (RR, 0.82; 95% CI, 0.65–1.02; P=0.07; and I2 = 45%) and overall mortality (RR, 0.86; 95% CI, 0.74–1.01; P=0.06; and I2 = 51%) of patients with sepsis. Moreover, the SOFA score of patients with sepsis improved significantly after treatment with vitamin C for over 72 hours (RR, 0.26; 95% CI, 0.09–0.42; P=0.002; and I2 = 0%). The main results of our study were moderate-quality evidence. More high-quality, multicenter RCTs are needed to provide more substantial evidence on the efficacy and safety of IV vitamin C for sepsis.
ISSN:1368-5031
1742-1241
DOI:10.1155/2023/6733465