A new method of intraoperative pelvic neuromonitoring: a preclinical feasibility study in a porcine model

Low anterior resections (LAR) are frequently associated with complications such as urinary and fecal incontinence as well as sexual disorders. Typical risk factors are rectal cancer with low tumor location, preoperative radiotherapy, and surgery-related damage of pelvic autonomic nerves. As preservi...

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Bibliographic Details
Published in:Scientific reports 2022-03, Vol.12 (1), p.3696-3696, Article 3696
Main Authors: Schuler, Ramona, Goos, Matthias, Langer, Andreas, Meisinger, Maximilian, Marquardt, Christoph, Fritsch, Helga, Konschake, Marko
Format: Article
Language:English
Subjects:
692/308/575
692/4025/1334
692/698/1688/1959/1315
692/698/1864/1334
Animals
Feasibility Studies
Female
Humanities and Social Sciences
Humans
multidisciplinary
Pelvis - innervation
Pelvis - surgery
Prospective Studies
Rectal Neoplasms - surgery
Rectum - surgery
Science
Science (multidisciplinary)
Swine
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Summary:Low anterior resections (LAR) are frequently associated with complications such as urinary and fecal incontinence as well as sexual disorders. Typical risk factors are rectal cancer with low tumor location, preoperative radiotherapy, and surgery-related damage of pelvic autonomic nerves. As preserving the pelvic autonomic nerves without any technical assistance is challenging, the objective of this preclinical study was to investigate the technical feasibility of a new method for intraoperative pelvic neuromonitoring. Twelve female pigs undergoing low anterior resections were involved in a prospective preclinical study. Intraoperative pelvic neuromonitoring included direct pelvic nerve stimulation and tissue impedance measurement on the urinary bladder and the rectum for the identification of efferent pelvic nerves in the surgical area. Immunohistochemistry was used to verify the results. Smooth muscle contraction of the urinary bladder and/or the rectum in response to direct stimulation of the innervating nerves was detectable with impedance measurement. The macroscopic contraction of both the urinary bladder and the rectum correlated with a change in tissue impedance compared to the status before contraction. Thus, it was possible to identify pelvic nerves in the surgical area, which allows the nerves to be preserved. The results indicate a reliable identification of pelvic autonomic nerves, which allows nerve damage to be prevented in the future.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-07576-8