Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous

• Published in: Pediatric rheumatology online journal 2019-10, Vol.17 (1), p.69-69, Article 69
• Main Authors: Lee, Wan-Fang, Wu, Chao-Yi, Yang, Huang-Yu, Lee, Wen-I, Chen, Li-Chen, Ou, Liang-Shiou, Huang, Jing-Long
• Format: Article
• Language: English
• Subjects: ADAMTS13 Protein - blood; Adolescent; Angiopoietin-1 - blood; Angiopoietin-2 - blood; Biological markers; Biomarkers; Biomarkers - blood; Cardiovascular diseases; Care and treatment; Case-Control Studies; Diagnosis; Endothelial cell; Endothelial growth factors; Endothelium; Endothelium, Vascular - pathology; Enzyme-Linked Immunosorbent Assay; Enzymes; Female; Gastrointestinal system; Homeostasis; Humans; Lupus; Lupus erythematosus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - pathology; Male; Medical research; Pediatric research; Pediatrics; Proteins; Receptor, TIE-2 - blood; Skin; Systemic lupus erythematosus; Thrombomodulin - blood; Vascular diseases; Vascular Diseases - blood; Vascular Diseases - pathology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Young Adult
• ISSN: 1546-0096; 1546-0096
• DOI: 10.1186/s12969-019-0369-7

Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with potential extensive vascular lesions, involving skin vessels, renal glomeruli, cardiovascular system, brain, lung alveoli, gastrointestinal tract vessels and more. We aimed to assess endothelial dysregulation related biomarkers in pediatric-onset SLE (pSLE) patient serum and elucidate its correlation with their clinical features, laboratory parameters, and the overall disease activity. Disease activities were evaluated by SLE disease activity index (SLEDAI). Patient characteristics were obtained by retrospective chart review. Six biomarkers associated with endothelial dysregulation, including Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Tie2, Vascular endothelial growth factor (VEGF), thrombomodulin, and a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) were tested through enzyme-linked immunosorbent assay (ELISA) measurement. This study comprised 118 pSLE patients. Data from 40 age-matched healthy controls were also obtained. The mean diagnostic age was 13 ± 4.12 years-old and 90.7% are females. Serum levels of VEGF, Tie2, thrombomodulin were significantly higher while serum ADAMTS13 was lower in active pSLE patients when compared to those with inactive diseases (all p