Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey

Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression. To identify the relationships between clinicopathological characteristics...

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Published in:Balkan medical journal 2014-06, Vol.31 (2), p.126-131
Main Authors: Yıldız, Bülent, Fidan, Evren, Ozdemir, Feyyaz, Sezen, Orhan, Kavgacı, Halil, Aydın, Fazıl
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Breast neoplasms
disease free survival
Original
overall survival
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container_start_page 126
container_title Balkan medical journal
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creator Yıldız, Bülent
Fidan, Evren
Ozdemir, Feyyaz
Sezen, Orhan
Kavgacı, Halil
Aydın, Fazıl
description Triple-negative (TN) breast cancer is a subtype of breast cancer characterised by a loss of estrogen receptor (ER), progesterone receptor (PR) expression, and the absence of human epidermal growth factor (HER2) overexpression. To identify the relationships between clinicopathological characteristics of TN breast cancers in the northeast region of Turkey and disease free survival (DFS) and overall survival (OS). Retrospective clinical study. Seven hundred and eighty non-metastatic breast cancer patients were enrolled in this study. The relationships between TN breast cancer and other breast cancers with respect to clinicopathological characteristics, as well as DFS and OS, were studied. The triple-negative phenotype was detected in 204 patients (27.1%). Patients with triple-negative breast cancer had more grade 2-3 tumours compared to those with other types of breast cancer (92.5% versus 84.3%, p=0.004). Invasive ductal carcinoma histology, on the other hand, was less prevalent in patients with TN breast cancer (77% versus 84.5%, p=0.016). No significant differences were identified between the groups in other clinicopathological variables. Relapse and mortality rates were higher in the TN group during the follow-up of both groups [57 (27.9%) versus 89 (16.2%), p
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To identify the relationships between clinicopathological characteristics of TN breast cancers in the northeast region of Turkey and disease free survival (DFS) and overall survival (OS). Retrospective clinical study. Seven hundred and eighty non-metastatic breast cancer patients were enrolled in this study. The relationships between TN breast cancer and other breast cancers with respect to clinicopathological characteristics, as well as DFS and OS, were studied. The triple-negative phenotype was detected in 204 patients (27.1%). Patients with triple-negative breast cancer had more grade 2-3 tumours compared to those with other types of breast cancer (92.5% versus 84.3%, p=0.004). Invasive ductal carcinoma histology, on the other hand, was less prevalent in patients with TN breast cancer (77% versus 84.5%, p=0.016). No significant differences were identified between the groups in other clinicopathological variables. 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subjects Breast neoplasms
disease free survival
Original
overall survival
title Clinicopathological Characteristics of Triple-negative Breast Cancers in the Northeast Region of Turkey
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