Blastocyst complementation and interspecies chimeras in gene edited pigs

The only curative therapy for many endstage diseases is allograft organ transplantation. Due to the limited supply of donor organs, relatively few patients are recipients of a transplanted organ. Therefore, new strategies are warranted to address this unmet need. Using gene editing technologies, som...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2022-12, Vol.10, p.1065536-1065536
Main Authors: Choe, Yong-Ho, Sorensen, Jacob, Garry, Daniel J, Garry, Mary G
Format: Article
Language:English
Subjects:
blastocyst complementation
Cell and Developmental Biology
ETV2
Myf5
MyoD
pigs
somatic cell nuclear transfer
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Summary:The only curative therapy for many endstage diseases is allograft organ transplantation. Due to the limited supply of donor organs, relatively few patients are recipients of a transplanted organ. Therefore, new strategies are warranted to address this unmet need. Using gene editing technologies, somatic cell nuclear transfer and human induced pluripotent stem cell technologies, interspecies chimeric organs have been pursued with promising results. In this review, we highlight the overall technical strategy, the successful early results and the hurdles that need to be addressed in order for these approaches to produce a successful organ that could be transplanted in patients with endstage diseases.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.1065536