Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center

Acute kidney injury (AKI) is commonly seen in neonatal intensive care units (NICUs) and is potentially associated with adverse prognoses in later stages of life. Our study evaluated the impact of sustained AKI (SAKI) on both neurodevelopmental impairment (NDI) and early growth restriction (EGR) in n...

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Bibliographic Details
Published in:BMC pediatrics 2024-04, Vol.24 (1), p.233-11, Article 233
Main Authors: Yen, Chen-Wei, Chiang, Ming-Chou, Chu, Shih-Ming, Wang, Hsiao-Chin, Wu, Li-Chun, Yen, Po-Cheng, Yu, Mei-Ching
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - diagnosis
Acute Kidney Injury - etiology
Acute renal failure
Apgar score
Births
Blood pressure
Case-Control Studies
Child development deviations
Complications and side effects
Congenital diseases
Developmental disabilities
Diseases
Early growth restriction
Gestational age
Growth disorders
Hospitalization
Hospitals
Humans
Hypoxia
Infant, Newborn
Infants (Newborn)
Intensive care
Intensive Care Units, Neonatal
Ischemia
Kidney diseases
Length of stay
Lung diseases
Medical records
Mortality
Neonatal care
Neonatal intensive care unit
Neurodevelopment impairment
Newborn babies
Pediatric research
Pediatrics
Premature babies
Retrospective Studies
Review boards
Risk Factors
Ventilators
Citations: Items that this one cites
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Summary:Acute kidney injury (AKI) is commonly seen in neonatal intensive care units (NICUs) and is potentially associated with adverse prognoses in later stages of life. Our study evaluated the impact of sustained AKI (SAKI) on both neurodevelopmental impairment (NDI) and early growth restriction (EGR) in neonates. This case-control study retrospectively analyzed the medical records of neonates diagnosed with SAKI in the NICU of a tertiary medical center during the period from January 2007 to December 2020. Cases without subsequent follow-up and those resulting in death were excluded. We analyzed demographic, biochemical, and clinical outcome data. Of the 93 neonates with SAKI, 51 cases (54.8%) were included in this study, while 42 cases (45.2%) were excluded due to a lack of follow-up or death. An age-matched control group comprised 103 neonates, who had never experienced AKI or SAKI, were selected at random. In total, 59 (38.3%) cases were identified as NDI and 43 (27.9%) as EGR. Multivariate analysis revealed that patients with SAKI had significantly higher risks of developing NDI (odds ratio, [OR] = 4.013, p = 0.001) and EGR (OR = 4.894, p 
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-024-04568-7