Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain

Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive. It is assumed that abnormal increase of...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2020, Vol.2020 (2020), p.1-13
Main Authors: Jia, Dong, Chu, Wen-Guang, Ma, Sui-Bin, Sun, Zhi-Chuan, Luo, Ceng
Format: Article
Language:English
Subjects:
Amino acids
Animals
Brain - physiopathology
Calcium Signaling
Chronic pain
Cloning
Ganglia, Spinal - physiopathology
Humans
Kinases
Nervous system
Neural Pathways - physiopathology
Neurons - physiology
Neurophysiology
Nociception - physiology
Pain
Pain - physiopathology
Permeability
Physiological aspects
Physiology
Review
Spinal cord
Transient Receptor Potential Channels - physiology
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Summary:Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain elusive. It is assumed that abnormal increase of calcium levels in the cells is a key determinant in the transition from acute to chronic pain. Exploring molecular players mediating Ca2+ entry into cells and molecular mechanisms underlying activity-dependent changes in Ca2+ signaling in the somatosensory pain pathway is therefore helpful towards understanding the development of chronic, pathological pain. Canonical transient receptor potential (TRPC) channels form a subfamily of nonselective cation channels, which permit the permeability of Ca2+ and Na+ into the cells. Initiation of Ca2+ entry pathways by these channels triggers the development of many physiological and pathological functions. In this review, we will focus on the functional implication of TRPC channels in nociception with the elucidation of their role in the detection of external stimuli and nociceptive hypersensitivity.
ISSN:2090-5904
0792-8483
1687-5443
DOI:10.1155/2020/3764193