Association of MicroRNA-103 expression with type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM), the most prevalent metabolic disorder worldwide, has genetic, epigenetic, and environmental contributors. Among them, circulating microRNAs (miRNAs/miRs) have attracted considerable attention. This study aimed to investigate the regulatory role of miR-103 in T2DM dev...

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Bibliographic Details
Published in:Caspian journal of internal medicine 2025, Vol.16 (1), p.106-113
Main Authors: Rafiee, Mahnoosh, Sadeghi, Farzin, Mirzapour, Ali, Khafri, Soraya, Korani, Bahare, Al-E-Ahmad, Atiyeh, Parsian, Hadi
Format: Article
Language:English
Subjects:
insulin resistance
micrornas
mir-103
Original
type 2 diabetes mellitus
Online Access:Get full text
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Summary:Type 2 diabetes mellitus (T2DM), the most prevalent metabolic disorder worldwide, has genetic, epigenetic, and environmental contributors. Among them, circulating microRNAs (miRNAs/miRs) have attracted considerable attention. This study aimed to investigate the regulatory role of miR-103 in T2DM development. The miR-103 expression was evaluated in 33 participants with T2DM compared with 38 healthy controls using quantitative real-time polymerase chain reaction (q-RT PCR). Fasting blood glucose (FBS), fasting insulin (Fin), hemoglobin A1c (HbA1c), triglycerides (TG), and cholesterol (Chol) were also determined in serum. Basal insulin resistance and sensitivity were determined using the homeostasis model assessment insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI), respectively. There was a significant decrease in miR-103 levels in patients with T2DM (p
ISSN:2008-6164
2008-6172
DOI:10.22088/cjim.16.1.106