Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-06, Vol.24 (12), p.2336
Main Authors: Remy, Simon, Litaudon, Marc
Format: Article
Language:English
Subjects:
Activation
Animals
Antiviral activity
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Biodiversity
Chemical Sciences
chikungunya
Chikungunya Fever - drug therapy
Chikungunya Fever - virology
Chikungunya virus
Chikungunya virus - drug effects
Chikungunya virus - physiology
Cytotoxicity
daphnane
Diterpenes
Diterpenes - chemistry
Diterpenes - pharmacology
Drug development
Epidemics
Epithelial cells
Euphorbiaceae
Euphorbiaceae - chemistry
flexibilane
Flowers & plants
HIV
Human immunodeficiency virus
Humans
ingenane
jatrophane
Kinases
Latent infection
Molecular Structure
phorbol
PKC
Plant Extracts - chemistry
Plant Extracts - pharmacology
Platelet aggregation
pre-myrsinane
Protein kinase C
Review
Structure-Activity Relationship
tigliane
Tumors
Vector-borne diseases
Vero cells
Virus Replication - drug effects
Viruses
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Description
Summary:Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure-activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24122336