Prognostic factors of pacing-induced cardiomyopathy

The detrimental outcomes of right ventricular pacing on left ventricular electromechanical function ultimately result in heart failure, a phenomenon termed pacing-induced cardiomyopathy (PICM) in clinical research. This study aimed to validate prognostic factors that can be used to identify patients...

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Bibliographic Details
Published in:Chinese medical journal 2020-07, Vol.133 (13), p.1533-1539
Main Authors: Zhang, Hong, Zhou, Yu-Jie, Zeng, Yu-Jie
Format: Article
Language:English
Subjects:
Body mass index
Cardiac Pacing, Artificial
Cardiomyopathies - etiology
Cardiomyopathy
Ejection fraction
Heart
Heart Failure - etiology
Heart Failure - therapy
Humans
Hypertension
Male
Multivariate analysis
Original
Ostomy
Pacemakers
Prognosis
Retrospective Studies
Stroke Volume
Ultrasonic imaging
Veins & arteries
Ventricular Function, Left
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Summary:The detrimental outcomes of right ventricular pacing on left ventricular electromechanical function ultimately result in heart failure, a phenomenon termed pacing-induced cardiomyopathy (PICM) in clinical research. This study aimed to validate prognostic factors that can be used to identify patients with higher susceptibility to progress to the stage of cardiomyopathy before pacemaker implantation. This observational analysis enrolled 256 patients between January 2013 and June 2016, 23 (8.98%) of whom progressed to PICM after 1 year of follow-up. A Cox proportional hazard model was used to analyze the prognostic factors associated with PICM. Dose-response analysis was used to evaluate the relationship between significant indicators in multifactor analysis and PICM. The mean values of left ventricular ejection fraction before and after pacemaker implantation in 23 patients diagnosed with PICM were 62.3% and 42.7%, respectively. Univariate analysis showed that sex, atrio-ventricular block, paced QRS duration, and ventricular pacing percentage were significantly associated with PICM. In the multivariate analysis, male sex (hazard ratio: 1.20, 95% confidence interval [CI]: 1.09-1.33, P 
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000000856