Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes

In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. U...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2019, Vol.84 (11), p.1319-1327
Main Authors: Lovic, Jelena, Ladjarevic, Jelena, Mijin, Dusan, Jadranin, Milka, Petrovic, Slobodan, Avramov-Ivic, Milka
Format: Article
Language:English
Subjects:
au electrode
cyclic voltammetry
gc electrode
irox electrode
square wave voltammetry
total organic carbon analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c342t-8231e57994ea57173d3c42b215dbcd5ef160a5ddd3ad7e26efc3307541d243143
cites
container_end_page 1327
container_issue 11
container_start_page 1319
container_title Journal of the Serbian Chemical Society
container_volume 84
creator Lovic, Jelena
Ladjarevic, Jelena
Mijin, Dusan
Jadranin, Milka
Petrovic, Slobodan
Avramov-Ivic, Milka
description In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.
doi_str_mv 10.2298/JSC190731091L
format article
fullrecord <record><control><sourceid>doaj_cross</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_1b54d40a80284ef487eaa7cff4e4eafd</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_1b54d40a80284ef487eaa7cff4e4eafd</doaj_id><sourcerecordid>oai_doaj_org_article_1b54d40a80284ef487eaa7cff4e4eafd</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-8231e57994ea57173d3c42b215dbcd5ef160a5ddd3ad7e26efc3307541d243143</originalsourceid><addsrcrecordid>eNpV0E1Lw0AQBuBFFKzVo_f9AUb3s5scS6htpZhD9Rwmu7M2Je3KZov23xutCMLADMPwDLyE3HJ2L0SRPzytS14wIzkr-OqMjHguWGaU4OdkxKQWmeayuCRXfb9lTGgt1YhsZh3aFIPd4K610NE-QdN2bTrS4OkOkw9x1-7pUM-wKCtJYe-GUawrRT8gYaR96A6pDXsKiU4Pd3Re_twsY_VJ8aQ77K_JhYeux5vfPiavj7OXcpGtqvmynK4yK5VIWS4kR22KQiFow4100irRCK5dY51GzycMtHNOgjMoJuitlMxoxZ1Qkis5JsuT6wJs6_fY7iAe6wBt_bMI8a2GmFrbYc0brZxikDORK_QqNwhgrPcKh-_eDVZ2smwMfR_R_3mc1d-R1_8il1-Ev3Mk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes</title><source>Free Full-Text Journals in Chemistry</source><creator>Lovic, Jelena ; Ladjarevic, Jelena ; Mijin, Dusan ; Jadranin, Milka ; Petrovic, Slobodan ; Avramov-Ivic, Milka</creator><creatorcontrib>Lovic, Jelena ; Ladjarevic, Jelena ; Mijin, Dusan ; Jadranin, Milka ; Petrovic, Slobodan ; Avramov-Ivic, Milka</creatorcontrib><description>In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.</description><identifier>ISSN: 0352-5139</identifier><identifier>EISSN: 1820-7421</identifier><identifier>DOI: 10.2298/JSC190731091L</identifier><language>eng</language><publisher>Serbian Chemical Society</publisher><subject>au electrode ; cyclic voltammetry ; gc electrode ; irox electrode ; square wave voltammetry ; total organic carbon analysis</subject><ispartof>Journal of the Serbian Chemical Society, 2019, Vol.84 (11), p.1319-1327</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-8231e57994ea57173d3c42b215dbcd5ef160a5ddd3ad7e26efc3307541d243143</citedby><orcidid>0000-0001-5691-2971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Lovic, Jelena</creatorcontrib><creatorcontrib>Ladjarevic, Jelena</creatorcontrib><creatorcontrib>Mijin, Dusan</creatorcontrib><creatorcontrib>Jadranin, Milka</creatorcontrib><creatorcontrib>Petrovic, Slobodan</creatorcontrib><creatorcontrib>Avramov-Ivic, Milka</creatorcontrib><title>Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes</title><title>Journal of the Serbian Chemical Society</title><description>In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.</description><subject>au electrode</subject><subject>cyclic voltammetry</subject><subject>gc electrode</subject><subject>irox electrode</subject><subject>square wave voltammetry</subject><subject>total organic carbon analysis</subject><issn>0352-5139</issn><issn>1820-7421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpV0E1Lw0AQBuBFFKzVo_f9AUb3s5scS6htpZhD9Rwmu7M2Je3KZov23xutCMLADMPwDLyE3HJ2L0SRPzytS14wIzkr-OqMjHguWGaU4OdkxKQWmeayuCRXfb9lTGgt1YhsZh3aFIPd4K610NE-QdN2bTrS4OkOkw9x1-7pUM-wKCtJYe-GUawrRT8gYaR96A6pDXsKiU4Pd3Re_twsY_VJ8aQ77K_JhYeux5vfPiavj7OXcpGtqvmynK4yK5VIWS4kR22KQiFow4100irRCK5dY51GzycMtHNOgjMoJuitlMxoxZ1Qkis5JsuT6wJs6_fY7iAe6wBt_bMI8a2GmFrbYc0brZxikDORK_QqNwhgrPcKh-_eDVZ2smwMfR_R_3mc1d-R1_8il1-Ev3Mk</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Lovic, Jelena</creator><creator>Ladjarevic, Jelena</creator><creator>Mijin, Dusan</creator><creator>Jadranin, Milka</creator><creator>Petrovic, Slobodan</creator><creator>Avramov-Ivic, Milka</creator><general>Serbian Chemical Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5691-2971</orcidid></search><sort><creationdate>2019</creationdate><title>Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes</title><author>Lovic, Jelena ; Ladjarevic, Jelena ; Mijin, Dusan ; Jadranin, Milka ; Petrovic, Slobodan ; Avramov-Ivic, Milka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-8231e57994ea57173d3c42b215dbcd5ef160a5ddd3ad7e26efc3307541d243143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>au electrode</topic><topic>cyclic voltammetry</topic><topic>gc electrode</topic><topic>irox electrode</topic><topic>square wave voltammetry</topic><topic>total organic carbon analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lovic, Jelena</creatorcontrib><creatorcontrib>Ladjarevic, Jelena</creatorcontrib><creatorcontrib>Mijin, Dusan</creatorcontrib><creatorcontrib>Jadranin, Milka</creatorcontrib><creatorcontrib>Petrovic, Slobodan</creatorcontrib><creatorcontrib>Avramov-Ivic, Milka</creatorcontrib><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the Serbian Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lovic, Jelena</au><au>Ladjarevic, Jelena</au><au>Mijin, Dusan</au><au>Jadranin, Milka</au><au>Petrovic, Slobodan</au><au>Avramov-Ivic, Milka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes</atitle><jtitle>Journal of the Serbian Chemical Society</jtitle><date>2019</date><risdate>2019</risdate><volume>84</volume><issue>11</issue><spage>1319</spage><epage>1327</epage><pages>1319-1327</pages><issn>0352-5139</issn><eissn>1820-7421</eissn><abstract>In this study the electrochemical behavior of metformin (MET), oral antihyperglycaemic agent, was assayed at three different electrodes. The drug standard was investigated by cyclic voltammetry and square wave voltammetry via its electrooxidation at Au and glassy carbon electrode in 0.05 M NaHCO3. Under these conditions transformation of MET to corresponding N-carbonyl guanidine via oxime intermediate is suggested. The stability of MET was tested under directed stress conditions using IrOx electrode with sodium sulphate as an electrolyte and cyclic 4-amino-2-imino-1-methyl-1,2-dihydro-1,3,5-triazine appeared as the main end-product. The courses of the electrochemical processes at three electrodes were followed by UV spectroscopy and evaluated by total organic carbon analysis.</abstract><pub>Serbian Chemical Society</pub><doi>10.2298/JSC190731091L</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5691-2971</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0352-5139
ispartof Journal of the Serbian Chemical Society, 2019, Vol.84 (11), p.1319-1327
issn 0352-5139
1820-7421
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_1b54d40a80284ef487eaa7cff4e4eafd
source Free Full-Text Journals in Chemistry
subjects au electrode
cyclic voltammetry
gc electrode
irox electrode
square wave voltammetry
total organic carbon analysis
title Electrochemical stability of metformin in NaHCO3 and Na2SO4 water solution at Au, GC and IrOx electrodes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T02%3A00%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-doaj_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electrochemical%20stability%20of%20metformin%20in%20NaHCO3%20and%20Na2SO4%20water%20solution%20at%20Au,%20GC%20and%20IrOx%20electrodes&rft.jtitle=Journal%20of%20the%20Serbian%20Chemical%20Society&rft.au=Lovic,%20Jelena&rft.date=2019&rft.volume=84&rft.issue=11&rft.spage=1319&rft.epage=1327&rft.pages=1319-1327&rft.issn=0352-5139&rft.eissn=1820-7421&rft_id=info:doi/10.2298/JSC190731091L&rft_dat=%3Cdoaj_cross%3Eoai_doaj_org_article_1b54d40a80284ef487eaa7cff4e4eafd%3C/doaj_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c342t-8231e57994ea57173d3c42b215dbcd5ef160a5ddd3ad7e26efc3307541d243143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true