Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy - a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol

Approximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10-15% of CRLM are initially considered resectable. The objective response rates (ORR) after cur...

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Bibliographic Details
Published in:BMC cancer 2020-01, Vol.20 (1), p.74-74, Article 74
Main Authors: Boilève, Alice, Maillard, Aline, Wagner, Mathilde, Dromain, Clarisse, Laurent, Christophe, Dupont Bierre, Eric, Le Sourd, Samuel, Audemar, Franck, Ulusakarya, Ayhan, Guerin-Meyer, Veronique, Smisth, Denis, Pezzella, Veronica, De Baere, Thierry, Goere, Diane, Gelli, Maximiliano, Taieb, Julien, Boige, Valérie
Format: Article
Language:English
Subjects:
Abdomen
Bevacizumab
Cancer
Cancer therapies
Catheters
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Epidermal growth factor receptors
Hepatic arterial infusion
Human health and pathology
Hépatology and Gastroenterology
Life Sciences
Liver
Liver metastases
Liver resection
Medical prognosis
Metastases
Metastasis
Monoclonal antibodies
Objectives
Oxaliplatin
Pharmaceutical sciences
Pharmacology
Quality of life
Randomized trial
Response rates
Study Protocol
Surgery
Survival
Targeted cancer therapy
Toxicity
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Summary:Approximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10-15% of CRLM are initially considered resectable. The objective response rates (ORR) after current first-line systemic chemotherapy (sys-CT) regimens range from 40 to 80% and complete resection rates (CRR) range from 25 to 50% in patients with initially unresectable CRLM. When CRLM patients are not amenable to complete resection after induction of sys-CT, ORRs obtained with second-line sys-CT are much lower (between 10 and 30%) and consequently CRRs are also low (
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-6571-7