Evaluating environmental persistence and disinfection of the Ebola virus Makona variant

The current disease outbreak caused by the Ebola virus Makona variant (EBOV/Mak) has led to unprecedented morbidity and lethality given its geographic reach and sustained transmission. Sodium hypochlorite and ethanol are well-accepted decontamination agents, however little published evidence support...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2015-04, Vol.7 (4), p.1975-1986
Main Authors: Cook, Bradley W M, Cutts, Todd A, Nikiforuk, Aidan M, Poliquin, Philip Guillaume, Court, Deborah A, Strong, James E, Theriault, Steven S
Format: Article
Language:English
Subjects:
biosafety
Disease control
Disinfectants - pharmacology
disinfection
Disinfection & disinfectants
Disinfection - methods
Ebola virus
ebolavirus
Ebolavirus - drug effects
Ebolavirus - isolation & purification
Ebolavirus - physiology
Electronic mail systems
environment
Environmental Microbiology
Epidemics
Ethanol
Ethanol - pharmacology
filovirus
Makona
Microbial Viability
Molecular Sequence Data
outbreak management
Proteins
Public health
Sequence Analysis, DNA
Sodium
sodium hypochlorite
Sodium Hypochlorite - pharmacology
Stainless steel
Time Factors
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The current disease outbreak caused by the Ebola virus Makona variant (EBOV/Mak) has led to unprecedented morbidity and lethality given its geographic reach and sustained transmission. Sodium hypochlorite and ethanol are well-accepted decontamination agents, however little published evidence supports the selection of appropriate concentrations and contact times. The present study addresses the environmental robustness of EBOV/Mak and evaluates the effectiveness of sodium hypochlorite and ethanol as disinfectants. EBOV/Mak was suspended in a simulated organic soil load and dried onto surfaces. Viability was measured at 1 hour, 24 hours, 72 hours, and 192 hours. For the evaluation of disinfectants, EBOV/Mak in a simulated organic soil was dried onto stainless steel carriers and disinfected with 0.01% (v/v), 0.1% (v/v), 0.5% (v/v) and 1% (v/v) sodium hypochlorite solutions or 67% (v/v) ethanol at contact times of 1, 5 or 10 minutes. EBOV/Mak persisted longer on steel and plastic surfaces (192 hours) than cotton (
ISSN:1999-4915
1999-4915
DOI:10.3390/v7041975