Emergency management of a 13-year-old patient with primary mediastinal B cell lymphoma: Extracorporeal membrane oxygenation and superior vena cava stent prior to chemotherapy

Primary mediastinal B cell lymphoma (PMBCL) is a rare type of non-Hodgkin's lymphoma, and prompt diagnosis and initiation of chemotherapy are necessary to limit compression of cardiovascular structures. A 13-year-old patient was diagnosed with PMBCL, resulting in acute hypoxemic respiratory fai...

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Bibliographic Details
Published in:Pediatric hematology oncology journal 2024-09, Vol.9 (3), p.129-132
Main Authors: Maffei, Salvador R., Stapleton, Gary, Doane, Katherine, Thomas, James, Tcharmtchi, M Hossein, Brackett, Julienne, Bhar, Saleh
Format: Article
Language:English
Subjects:
Extracorporeal membrane oxygenation
Interventional cardiology
Mediastinal mass
Superior vena cava syndrome
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Summary:Primary mediastinal B cell lymphoma (PMBCL) is a rare type of non-Hodgkin's lymphoma, and prompt diagnosis and initiation of chemotherapy are necessary to limit compression of cardiovascular structures. A 13-year-old patient was diagnosed with PMBCL, resulting in acute hypoxemic respiratory failure and cardiogenic shock with clinical pericardial tamponade. Chemotherapy was initiated after veno-arterial extracorporeal membrane oxygenation and subsequent endovascular stenting of the superior vena cava (SVC) to optimize cardiac output due to malignant SVC syndrome. We discuss the challenges of diagnosis and emergency management of pediatric patients with PMBCL and review the existing relevant literature for SVC syndrome secondary to PMBCL.
ISSN:2468-1245
2468-1245
DOI:10.1016/j.phoj.2024.03.010