Association of Paclitaxel Induced Neuropathy with Quality of Life of Patients with Non-Metastatic Breast Cancer

Objective: To look for an association of Paclitaxel induced neuropathy with the quality of Life of patients with non-metastatic breast cancer. Study Design: Comparative cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Nov...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2023-06, Vol.73 (3), p.755-58
Main Authors: Masood, Masaba, Nadeem, Muhammad, Masood, Amna, Ali, Aamira, Tufail, Muhammad Umair
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Comorbidity
Data analysis
Illnesses
Metastasis
Neurotoxicity
Oncology
Paclitaxel
Peripheral neuropathy
Quality of life
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To look for an association of Paclitaxel induced neuropathy with the quality of Life of patients with non-metastatic breast cancer. Study Design: Comparative cross-sectional study. Place and Duration of Study: Oncology Department, Combined Military Hospital, Rawalpindi Pakistan, from Nov 2021 to Feb 2022. Methodology: The study included one hundred and twenty patients with diagnosed non-metastatic breast cancer taking Paclitaxel chemotherapy for more than one month. Peripheral neurotoxicity was assessed by a consultant oncologist based on the Eastern Cooperative Oncology Group (ECOG) score. In addition, quality of Life was recorded with the help of the World Health Organization Quality of Life (WHOQOL)-BREF scale in all the study participants and associated with the presence and severity of neuropathy. Results: Out of 120 non-metastatic breast cancer patients using Paclitaxel for more than one month included in the study, 113 (94.2%) were female, while 7(5.8%) were male. 52(48.3%) had good quality of Life, while 68(51.7%) had poor quality of Life. 34(28.3%) had Grade-0 neuropathy, 54 (45%) had Grade-I, 30(25%) had Grade-II, and 2(1.6%) had Grade-III neuropathy.Statistical analysis showed that the presence and severity of neurotoxicity had a statistically significant relationship with poor quality of Life (p-value=0.001). Conclusion: Many patients having breast cancer using Paclitaxel had the presence of neuropathy. The presence and severity of neuropathy are strongly associated with poor quality of Life in patients included in our study.Keywords: Breast cancer, Neurotoxicity, Paclitaxel, Quality of life.
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v73i3.8349