Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle w...

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Bibliographic Details
Published in:Therapeutic advances in vaccines and immunotherapy 2023-01, Vol.11
Main Authors: Jonny, Putranto, Terawan Agus, Purnama, Yenny, Djatmiko, Roedi, Yana, Martina Lily, Sitepu, Enda Cindylosa, Irfon, Raoulian
Format: Article
Language:English
Subjects:
Antinuclear antibodies
Autoimmune diseases
Case Report
Case reports
Dendritic cells
Dyspnea
Immunosuppressive agents
Immunotherapy
Lupus
Neuropathy
Peripheral blood
Peripheral neuropathy
Respiration
Serositis
Severe acute respiratory syndrome coronavirus 2
Stomatitis
Systemic lupus erythematosus
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Summary:Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness. The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. Immunosuppressants failed to improve the condition. DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient. There was a significant improvement in clinical and laboratory findings. Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied.
ISSN:2515-1355
2515-1363
DOI:10.1177/25151355231186005