Perfusion and pulsatile pressure: their relationship with target organ damage in the African-PREDICT study

Hypertension is the leading risk factor for subclinical target-organ damage (TOD) and cardiovascular disease (CVD). Little is known about the relationship between different pressure measures and subclinical TOD, especially in young populations. We compared the strength of associations of subclinical...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2024-08, Vol.24 (1), p.399-9, Article 399
Main Authors: Rooi, Donavan, Botha-Le Roux, Shani, Breet, Yolandi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Analysis
Arterial Pressure
Arterial stiffness
Black People
Blood pressure
Blood Pressure Monitoring, Ambulatory
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Carotid Intima-Media Thickness
Carotid-Femoral Pulse Wave Velocity
Chronic illnesses
Complications and side effects
Creatinine
Cross-Sectional Studies
Demographic aspects
Echocardiography
Female
Health aspects
Heart
Heart failure
Humans
Hypertension
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - physiopathology
Inflation rates
Male
Mean arterial pressure
Perfusion
Predictive Value of Tests
Prevention
Pulsatile Flow
Pulse pressure
Pulse Wave Analysis
Questionnaires
Retinal vessel calibres
Risk Assessment
Risk Factors
Self report
Socioeconomic factors
Socioeconomic status
South Africa - epidemiology
Ultrasonic imaging
Vascular Stiffness
Veins & arteries
Young Adult
Young adults
Young men
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Summary:Hypertension is the leading risk factor for subclinical target-organ damage (TOD) and cardiovascular disease (CVD). Little is known about the relationship between different pressure measures and subclinical TOD, especially in young populations. We compared the strength of associations of subclinical TOD markers with perfusion and pulsatile pressure in young adults. A total of 1 187 young adults from the African-PREDICT study were included. Ambulatory mean arterial pressure (MAP) and pulse pressure (PP) was obtained. Markers of subclinical TOD were measured and included left ventricular mass index (LVMi), carotid intimamedia thickness (cIMT), carotidfemoral pulse wave velocity (cfPWV), central retinal arteriolar equivalent (CRAE) and albumin to creatinine ratio (ACR). Measures of sub-clinical TOD (cIMT, cfPWV and CRAE), associated stronger with perfusion pressure (all p 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-024-04071-y