A Radiomics Approach to Predict the Emergence of New Hepatocellular Carcinoma in Computed Tomography for High-Risk Patients with Liver Cirrhosis

Liver cirrhosis poses a major risk for the development of hepatocellular carcinoma (HCC). This retrospective study investigated to what extent radiomic features allow the prediction of emerging HCC in patients with cirrhosis in contrast-enhanced computed tomography (CECT). A total of 51 patients wit...

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Bibliographic Details
Published in:Diagnostics (Basel) 2021-09, Vol.11 (9), p.1650
Main Authors: Tietz, Eric, Truhn, Daniel, Müller-Franzes, Gustav, Berres, Marie-Luise, Hamesch, Karim, Lang, Sven Arke, Kuhl, Christiane Katharina, Bruners, Philipp, Schulze-Hagen, Maximilian
Format: Article
Language:English
Subjects:
Automation
hepatocellular carcinoma
Liver cancer
Liver cirrhosis
Magnetic resonance imaging
Medical imaging
Patients
radiomics
Surveillance
tumor prediction
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Summary:Liver cirrhosis poses a major risk for the development of hepatocellular carcinoma (HCC). This retrospective study investigated to what extent radiomic features allow the prediction of emerging HCC in patients with cirrhosis in contrast-enhanced computed tomography (CECT). A total of 51 patients with liver cirrhosis and newly detected HCC lesions (n = 82) during follow-up (FU-CT) after local tumor therapy were included. These lesions were not to have been detected by the radiologist in the chronologically prior CECT (PRE-CT). For training purposes, segmentations of 22 patients with liver cirrhosis but without HCC-recurrence were added. A total of 186 areas (82 HCCs and 104 cirrhotic liver areas without HCC) were analyzed. Using univariate analysis, four independent features were identified, and a multivariate logistic regression model was trained to classify the outlined regions as “HCC probable” or “HCC improbable”. In total, 60/82 (73%) of segmentations with later detected HCC and 84/104 (81%) segmentations without HCC were classified correctly (AUC of 81%, 95% CI 74–87%), yielding a sensitivity of 72% (95% CI 57–83%) and a specificity of 86% (95% CI 76–96%). In conclusion, the model predicted the occurrence of new HCCs within segmented areas with an acceptable sensitivity and specificity in cirrhotic liver tissue in CECT.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11091650