Spasmolytic effect of traditional herbal formulation on guinea pig ileum

The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal pain. The present study was undertaken to evaluate safety a...

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Bibliographic Details
Published in:Journal of ayurveda and integrative medicine 2015-07, Vol.6 (3), p.194-197
Main Authors: Kumar, Dushyant, Ganguly, Kuntal, Hegde, H V, Patil, P A, Kholkute, S D
Format: Article
Language:English
Subjects:
Abdominal pain
Acetylcholine
Analgesics
Animals
Antispasmodics
Ayurvedic medicine
Care and treatment
Herbal medicine
histamine
Ingredients
Medical research
Mortality
Original
Pain
Rural areas
Seeds
spasmolytic activity
Studies
traditional formulation
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Summary:The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal pain. The present study was undertaken to evaluate safety and spasmolytic effect of poly-herbal formulation. Acute toxicity studies were carried out in Swiss mice, as per the Organization for Economic Co-operation and Development (OECD) guidelines. The spasmolytic activity of the formulation was studied in isolated guinea pig ileum model using histamine and acetylcholine as agonists. The data were analyzed by one-way ANOVA, followed by Dunnetts post-hoc test and P ≤ 0.05 was considered as significant. The formulation did not show any adverse toxic effects and found to be safe. It also showed significant (P < 0.05) relaxation in different agonist like histamine and acetylcholine-induced contractions in guinea pig ileum. Antispasmodic activity of the herbal formulation can be attributed to its atropine-like activity. The present findings, therefore, support its utility in spasmodic abdominal pain.
ISSN:0975-9476
0976-2809
DOI:10.4103/0975-9476.157954