Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial

Aim: The aim of the study was to evaluate and compare the analgesic efficacy of placebo and diazepam in patients with temporomandibular disorder. Materials and Methods: Thirty-five patients were recruited with a diagnosis of temporomandibular disorder based on standard clinical diagnostic criteria f...

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Bibliographic Details
Published in:Indian journal of dental research 2011-05, Vol.22 (3), p.404-409
Main Authors: Pramod, G, Shambulingappa, P, Shashikanth, M, Lele, Shailesh
Format: Article
Language:English
Subjects:
Analgesic efficacy
Analgesics
Chronic illnesses
Clinical medicine
Clinical trials
Data collection
Diazepam
double-blind randomized clinical trial
Drug therapy
Medical research
Medicine, Experimental
Methods
Pain management
placebo
temporomandibular disorders
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Summary:Aim: The aim of the study was to evaluate and compare the analgesic efficacy of placebo and diazepam in patients with temporomandibular disorder. Materials and Methods: Thirty-five patients were recruited with a diagnosis of temporomandibular disorder based on standard clinical diagnostic criteria for temporomandibular disorder. The patients were put in to one of the two groups: placebo or diazepam at random. The average pain intensity was recorded with visual analog scale (VAS) at pretreatment, at weekly interval till the completion of a three-week trial and at post-treatment visit on the eighth week from baseline. The secondary outcome measures were changes in masticatory muscle tenderness, viz. massater muscle, lateral pterygoid muscle, medial pterygoid muscle and temporalis muscle and changes in mouth opening. Statistical Analysis: Intra-group comparison for analgesic efficacy and mouth opening was carried out by Wilcoxon's signed ranked test. Inter-group comparison for analgesic efficacy was also carried out using Mann-Whitney's test. Results: A statistically significant (P
ISSN:0970-9290
1998-3603
DOI:10.4103/0970-9290.87062