Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer's Disease

Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer's disease (AD) with obscure pathogenesis. While the exact mech...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-05, Vol.21 (9), p.3226
Main Authors: Martins, Gabriela Lopes, Duarte, Rita Carolina Figueiredo, Mukhamedyarov, Marat A, Palotás, András, Ferreira, Cláudia Natália, Reis, Helton José
Format: Article
Language:English
Subjects:
Age
Alzheimer Disease - physiopathology
Alzheimer's disease
anti-inflammatory therapy
Arrhythmia
atrial fibrillation
Atrial Fibrillation - physiopathology
Brain
Cardiac arrhythmia
Cardiovascular disease
Cognitive Dysfunction - physiopathology
Cytokines
Dementia
Dementia - physiopathology
Dementia disorders
endothelial damage
Fibrillation
Heart failure
Humans
Infections - physiopathology
Inflammation
Inflammation - physiopathology
Models, Biological
Neuropathology
Pathogenesis
Permeability
Review
Risk Factors
Stroke - physiopathology
Studies
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Summary:Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer's disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21093226