Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play cruci...

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Bibliographic Details
Published in:Cancer cell international 2021-06, Vol.21 (1), p.313-17, Article 313
Main Authors: He, Jieyu, Ling, Lin, Liu, Zhongyue, Ren, Xiaolei, Wan, Lu, Tu, Chao, Li, Zhihong
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Bone cancer
Bone tumors
Breast cancer
Cancer therapies
Cell differentiation
Cell growth
Cell proliferation
Chemoresistance
Drug resistance
Genomes
Kinases
LncRNA
Medical prognosis
Metastases
Metastasis
Molecular modelling
Mutation
Non-coding RNA
Osteosarcoma
Pathogenesis
Phosphatase
Proteins
Review
Sarcoma
Signal transduction
Stemness
Tumorigenesis
Wnt
Wnt protein
Young adults
β-catenin
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Summary:Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-021-02013-8