Impairment of sleep homeostasis in cervical dystonia patients

Alterations in brain plasticity seem to play a role in the pathophysiology of cervical dystonia (CD). Since evidences indicate that sleep regulates brain plasticity, we hypothesized that an alteration in sleep homeostatic mechanisms may be involved in the pathogenesis of CD. We explored sleep in con...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2022-04, Vol.12 (1), p.6866-6866, Article 6866
Main Authors: Caverzasio, Serena, Amato, Ninfa, Chiaro, Giacomo, Staedler, Claudio, Kaelin-Lang, Alain, Galati, Salvatore
Format: Article
Language:English
Subjects:
631/378
692/617/375/1444
Botulinum toxin
Botulinum Toxins
Cytotoxicity
Dystonia
Homeostasis
Humanities and Social Sciences
Humans
Lymphocytes T
multidisciplinary
Neuronal Plasticity
Neuroplasticity
Patients
Physiology
Plasticity
Science
Science (multidisciplinary)
Sleep
Torticollis - drug therapy
Toxins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alterations in brain plasticity seem to play a role in the pathophysiology of cervical dystonia (CD). Since evidences indicate that sleep regulates brain plasticity, we hypothesized that an alteration in sleep homeostatic mechanisms may be involved in the pathogenesis of CD. We explored sleep in control subjects (CTL) and CD patients before (T pre-BoNT ) and after (T post-BoNT ) botulinum toxin (BoNT) treatment. A physiological slow wave activity (SWA) power decrease throughout the night was observed in CTL but not in CD at T pre-BoNT . BoNT restored the physiological SWA decrease in CD at T post-BoNT . Furthermore, in the first part of the night, CD at T post-BNT showed a frontal increase and parietal decrease in SWA power compared to CD at T pre-BoNT , with a SWA distribution comparable to that observed in CTL. Our data highlighted a pathophysiological relationship between SWA during sleep and CD and provided novel insight into the transient central plastic effect of BoNT.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10802-y