Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

The aim of this study was to improve the treatment of biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2021-04, Vol.14 (5), p.397
Main Authors: Benavent, Carlos, Torrado-Salmerón, Carlos, Torrado-Santiago, Santiago
Format: Article
Language:English
Subjects:
amorphous form
Antibiotics
Antifungal agents
Biofilms
Candida albicans
maltodextrin
Medical equipment
Morphology
nystatin
Polyvinyl alcohol
Scanning electron microscopy
solid dispersion
Spectrum analysis
Vibration
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Summary:The aim of this study was to improve the treatment of biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph14050397