Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma

• Published in: Respiratory research 2019-05, Vol.20 (1), p.102-10, Article 102
• Main Authors: Um-Bergström, Petra, Hallberg, Jenny, Pourbazargan, Melvin, Berggren-Broström, Eva, Ferrara, Giovanni, Eriksson, Maria J, Nyrén, Sven, Gao, Jing, Lilja, Gunnar, Lindén, Anders, Wheelock, Åsa M, Melén, Erik, Sköld, C Magnus
• Format: Article
• Language: English
• Subjects: Adolescent; Adults; Airway management; Asthma; Asthma - diagnosis; Asthma - epidemiology; Asthma - physiopathology; Astma; Birth weight; Bronchopulmonary dysplasia; Bronchopulmonary Dysplasia - diagnosis; Bronchopulmonary Dysplasia - epidemiology; Bronchopulmonary Dysplasia - physiopathology; Chronic obstructive pulmonary disease; Cohort Studies; Dysplasia; Female; Forced Expiratory Volume - physiology; Hospitals; Humans; Infant, Newborn; Inhomogeneity; Lung diseases; Lung function tests; Lungs; Male; Multiple births; Nitrogen dioxide; Oscillometry; Premature birth; Premature Birth - diagnosis; Premature Birth - epidemiology; Premature Birth - physiopathology; Quality of life; Quality of Life - psychology; Questionnaires; Respiratory diseases; Respiratory function; Respiratory Function Tests - methods; Respiratory tract; Risk analysis; Risk factors; Signs and symptoms; Spirometry; Ventilation; Young Adult; Young adults
• ISSN: 1465-993X; 1465-9921; 1465-993X; 1465-9921
• DOI: 10.1186/s12931-019-1075-1

Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypothesized that pulmonary outcomes and health-related quality of life (HRQoL) were different in adults born preterm with and without a history of BPD compared to asthmatics and healthy individuals. We evaluated 96 young adults from the LUNAPRE cohort ( clinicaltrials.gov/ct2/show/NCT02923648 ), including 26 individuals born preterm with a history of BPD (BPD), 23 born preterm without BPD (preterm), 23 asthmatics and 24 healthy controls. Extensive lung function testing and HRQoL were assessed. The BPD group had more severe airway obstruction compared to the preterm-, (FEV  0.94 vs. 0.28 z-scores; p ≤ 0.001); asthmatic- (0.14 z-scores, p ≤ 0.01) and healthy groups (0.78 z-scores, p ≤ 0.001). Further, they had increased ventilation inhomogeneity compared to the preterm- (LCI 6.97 vs. 6.73, p ≤ 0.05), asthmatic- (6.75, p = 0.05) and healthy groups (6.50 p ≤ 0.001). Both preterm groups had lower D compared to healthy controls (p ≤ 0.001 for both). HRQoL showed less physical but more psychological symptoms in the BPD group compared to asthmatics. Lung function impairment and HRQoL in adults with a history of BPD differed from that in asthmatics highlighting the need for objective assessment of lung health.