Invasive Fungal Infections in Under-Five Diarrheal Children: Experience from an Urban Diarrheal Disease Hospital

Invasive fungal infections (IFIs) are opportunistic, especially in immunocompromised and hospitalized patients. Children with IFIs are more vulnerable to a fatal outcome. For early diagnosis and treatment, knowledge of the spectrum and frequency of IFIs among children is prerequisite. In this prospe...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2022-01, Vol.12 (1), p.94
Main Authors: Shaly, Nusrat Jahan, Pervez, Mohammed Moshtaq, Huq, Sayeeda, Ahmed, Dilruba, Ahsan, Chowdhury Rafiqul, Sarmin, Monira, Afroze, Farzana, Nuzhat, Sharika, Chisti, Mohammod Jobayer, Ahmed, Tahmeed
Format: Article
Language:English
Subjects:
Antibiotics
Aspergillosis
Blood culture
Candidiasis
Children
death
Diagnosis
Diarrhea
Drug resistance
Enrollments
Enzyme-linked immunosorbent assay
Fever
Fungal infections
Fungi
Histoplasmosis
Hospitalization
Hospitals
Illnesses
Immune system
Infections
Intensive care
invasive fungal infections
Leukemia
Malnutrition
Morbidity
Mortality
Nosocomial infections
Pathogens
Patients
Pediatrics
Pneumonia
Sepsis
Septic shock
Sex
Steroid hormones
under-5-year-old children
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Summary:Invasive fungal infections (IFIs) are opportunistic, especially in immunocompromised and hospitalized patients. Children with IFIs are more vulnerable to a fatal outcome. For early diagnosis and treatment, knowledge of the spectrum and frequency of IFIs among children is prerequisite. In this prospective observational study, we enrolled 168 children of 2-59 months old of either sex from March 2018 to December 2019 admitted to the Dhaka hospital, icddr,b. Study participants with suspected IFIs were with or without severe acute malnutrition (SAM) along with sepsis/pneumonia and fulfilled any of the following criteria: (i) failure to respond to injectable antibiotics, (ii) development of a late-onset hospital-acquired infection, (iii) needed ICU care for >7 days, (iv) took steroids/antibiotics for >2 weeks before hospitalization, and (v) developed thrush after taking injectable antibiotics. The comparison group included non-SAM (weight-for-length Z score ≥ -2) children with diarrhea and fever
ISSN:2075-1729
2075-1729
DOI:10.3390/life12010094