Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment

Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with ferroptosis are discernible in both cancerous and immune cells...

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Published in:Journal of experimental & clinical cancer research 2024-01, Vol.43 (1), p.19-19, Article 19
Main Authors: Hua, Yuze, Yang, Sen, Zhang, Yalu, Li, Jiayi, Wang, Mengyi, Yeerkenbieke, Palashate, Liao, Quan, Liu, Qiaofei
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Antioxidants
Cancer
Cell Death
Cellular metabolism
Development and progression
Environmental aspects
Enzymes
Fatty acids
Ferroptosis
Health aspects
Humans
Hypoxia
Lymphocytes
Metabolism
Mitochondria
Neoplasms
Nitric oxide
Pancreatic cancer
Physiological aspects
Sapropterin dihydrochloride
Tumor immunity
Tumor Microenvironment
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Summary:Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with ferroptosis are discernible in both cancerous and immune cells. This review begins by delving into the intricate reciprocal regulation of ferroptosis between cancer and immune cells. It subsequently details how factors within the tumor microenvironment (TME) such as nutrient scarcity, hypoxia, and cellular density modulate ferroptosis sensitivity. We conclude by offering a comprehensive examination of distinct immunophenotypes and environmental and metabolic targets geared towards enhancing ferroptosis responsiveness within the TME. In sum, tailoring precise ferroptosis interventions and combination strategies to suit the unique TME of specific cancers may herald improved patient outcomes.
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-023-02925-5