Ferroptosis landscape in prostate cancer from molecular and metabolic perspective

Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays...

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Bibliographic Details
Published in:Cell death discovery 2023-04, Vol.9 (1), p.128-128, Article 128
Main Authors: Liang, Jiaming, Liao, Yihao, Wang, Pu, Yang, Kun, Wang, Youzhi, Wang, Keke, Zhong, Boqiang, Zhou, Diansheng, Cao, Qian, Li, Junbo, Zhao, Yang, Jiang, Ning
Format: Article
Language:English
Subjects:
631/208/2490
631/67/589/466
631/80/82
Androgens
Apoptosis
Autophagy
Biochemistry
Biomedical and Life Sciences
Cancer therapies
Castration
Cell Biology
Cell Cycle Analysis
Cell death
Cell growth
Disease
Ferroptosis
Genes
Hospitals
Life Sciences
Lipid peroxidation
Lipids
Medical prognosis
Metabolism
Metastases
Metastasis
Prostate cancer
Proteins
Review
Review Article
Stem Cells
Urology
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Summary:Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new effective anticancer methods. Ferroptosis is a novel iron-dependent programmed cell death that plays a role in various cancers. Understanding how ferroptosis is regulated in prostate cancer will help us to use it as a new way to kill cancer cells. In this review, we summarize the regulation and role of ferroptosis in prostate cancer and the relationship with AR from the perspective of metabolism and molecular pathways. We also discuss the feasibility of ferroptosis in prostate cancer treatment and describe current limitations and prospects, providing a reference for future research and clinical application of ferroptosis.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-023-01430-0