Synthesis of a Bioactive Nitric Oxide-Releasing Polymer from S‑Nitrosated Starch

• Published in: ACS omega 2024-10, Vol.9 (40), p.41268-41278
• Main Authors: da Silva, Jéssica Fernanda, de Almeida, Edson Araujo, Karoleski, Geovana Ellen, Koloshe, Everton, Peron, Ana Paula, Job, Aldo Eloizo, Leimann, Fernanda Vitória, Shirai, Marianne Ayumi, da Silva Gonzalez, Regiane
• Format: Article
• Language: English
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.4c03255

The incorporation of nitric oxide (NO) into polymeric matrices minimizes degradation and facilitates controlled release. This optimization increases the field of application of NO, in dressings, food protective films, and implant devices, among others. This work presents an economical and easy way to manufacture bioactive nitric oxide-releasing polymer (BioNOR-P) and evaluates its bactericidal and antioxidant activity (AA), mechanical behavior, cytotoxicity, and genotoxicity, seeking future use in different applications. The BioNOR-P film was obtained by a casting method, forming a homogeneous, transparent film with good mechanical properties. The release of NO in an aqueous medium showed the film’s ability to release NO slowly, at a rate of 0.58 nmol/g–1 min–1. Furthermore, the noncytotoxicity and antioxidant activity observed by NO release from BioNOR-P, as well as the ability to inhibit bacterial growth, may aid in the development of a NO-released polymer with different areas of application.