Renoprotective effect of remote ischemic postconditioning in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

Whether upper arm remote ischemic postconditioning (RIPostC) exerts protection to kidney in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains unknown. Sixty-four patients with STEMI were randomized to PPCI + RIPostC (n=29) a...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2018-01, Vol.14, p.369-375
Main Authors: Cao, Bangming, Zhang, Chi, Wang, Haipeng, Xia, Ming, Yang, Xiangjun
Format: Article
Language:English
Subjects:
Angioplasty
Balloon angioplasty
Care and treatment
Clinical trials
Clopidogrel
Creatine
Creatine kinase
Deflation (Economics)
Disease prevention
Echocardiography
Ejection fraction
Heart attack
Heart attacks
Intervention
Ischemia
Kidney diseases
Mortality
Myocardial ischemia
myocardial ischemia reperfusion
Normal distribution
Original Research
Patients
primary percutaneous coronary intervention
remote ischemic postconditioning
ST-segmental elevation myocardial infarction
Ticagrelor
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Summary:Whether upper arm remote ischemic postconditioning (RIPostC) exerts protection to kidney in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains unknown. Sixty-four patients with STEMI were randomized to PPCI + RIPostC (n=29) and PPCI (n=35) groups. RIPostC consisting of 4 cycles of 5 minutes occlusion/reperfusion by cuff inflation/deflation of the upper arm was started within 1 minute after the first balloon dilatation. Peripheral venous blood samples were collected before PPCI and at 0.5, 8, 24, 48, and 72 hours after PPCI to detect serum creatinine (SCr) and creatine kinase-MB (CK-MB). Acute kidney injury (AKI) rate and estimated glomerular filtration rate (eGFR) were calculated. The transthoracic echocardiography was performed 7 days after PPCI to assess left ventricular ejection fraction (LVEF). The patients in the PPCI + RIPostC group had a lower AKI rate compared with those in the PPCI group ( =0.04). The eGFR after PPCI increased in the PPCI + RIPostC group compared to the PPCI group (
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S158768