Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis

Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. The aim of thi...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2016-06, Vol.10 (6), p.ZC28-ZC31
Main Authors: Kulkarni, Ganesh, Sakki, Esther Priyadarshini, Kumar, Yennavaram Vijay, Kolimi, Sadananda, Perika, Ravi, Karthik, Kalepu Venkata, Kumar, Kandukuri Mahesh, Kalyan, Venumbaka Siva
Format: Article
Language:English
Subjects:
antigen presentation
antigens
dendritic cells
mouth mucosa
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Summary:Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test. LC population in OLP was significantly higher when compared to the normal epithelium (p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/19189.7966