Association between central obesity indices and iron status indicators among Qatari adults

• Published in: PloS one 2021-04, Vol.16 (4), p.e0250759
• Main Authors: Kerkadi, Abdelhamid, Mohsen Ali, Reem, A H Shehada, Alaa, Abdelnasser AbouHassanein, Eman, Moawad, Joyce, Bawadi, Hiba, Shi, Zumin
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adult; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - epidemiology; Biology and Life Sciences; Body size; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Female; Ferritins - blood; Health aspects; Humans; Iron - blood; Iron - metabolism; Iron deficiency anemia; Iron in the body; Male; Medicine and Health Sciences; Middle Aged; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - complications; Obesity, Abdominal - epidemiology; Prevalence; Qatar - epidemiology; Risk factors; Statistics; Waist Circumference; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0250759

Co-existence of iron deficiency and obesity in adults has been reported in many countries. However, little is known on the association between obesity and iron deficiency in Qatar. This study aimed to investigate the link between abdominal obesity indices and iron status among adults in Qatar. A random sample of 1000 healthy Qatari adults, aged 20-50 years, was obtained from Qatar Biobank study. Body weight, waist circumference, dual x-ray absorptiometry (DXA) parameters and iron status indicators were measured using standard techniques. Multiple regression analysis was used to examine the associations. The prevalence of iron deficiency and anaemia were 35.4 and 25%, respectively. Of the participants with a large waist circumference, 31.7% had anaemia. Ferritin significantly increased with the increase in the android fat to gynoid fat ratio and visceral fat in both genders. Serum iron and transferring saturation decreased significantly with the increase in waist circumference in women. In both genders, C-reactive protein increased with the increase in all obesity indices. Standardized values of waist circumference, android fat, gynoid fat ratio and visceral fat were significantly associated with log transformed ferritin in men and women. Waist circumference was inversely related to serum iron (β:-0.95, 95% CI:-1.50,-0.39) and transferrin saturation (β:-1.45, 95%CI:-2.46, -0.43) in women. In men, waist circumference was positively associated with haemoglobin level (β: 0.16, 95% CI:0.04, 0.29). Central obesity coexists with anaemia among the study population. Elevated central obesity indices were associated with an increase in ferritin concentration. The increased ferritin concentration may be attributed to the increase in inflammatory status as a result of an increase in c-reactive protein concentration associated with central obesity.