The Major Histocompatibility Complex in Transplantation

The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibilit...

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Bibliographic Details
Published in:Journal of Transplantation 2012-01, Vol.2012 (2012), p.389-395
Main Authors: Marco Antonio Ayala García, Beatriz González Yebra, Andrea Liliana López Flores, Eduardo Guaní Guerra
Format: Article
Language:English
Subjects:
Review
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Summary:The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. However, we should not forget that the innate and adaptive immunities are closely interrelated and should be viewed as complementary and cooperating. When a human transplant is performed, HLA (human leukocyte antigens) molecules from a donor are recognized by the recipient's immune system triggering an alloimmune response Matching of donor and recipient for MHC antigens has been shown to have a significant positive effect on graft acceptance. This paper will present MHC, the innate and adaptive immunities, and clinical HLA testing.
ISSN:2090-0007
2090-0015
DOI:10.1155/2012/842141