Abscopal effect of high-dose-rate brachytherapy on pelvic bone metastases from renal cell carcinoma: a case report

Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiatio...

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Bibliographic Details
Published in:Journal of contemporary brachytherapy 2019-01, Vol.11 (5), p.458-461
Main Authors: Suzuki, Gen, Masui, Koji, Yamazaki, Hideya, Takenaka, Tadashi, Asai, Syunsuke, Taniguchi, Hidefumi, Nakamura, Terukazu, Ukimura, Osamu, Yamada, Kei
Format: Article
Language:English
Subjects:
abscopal effect
brachytherapy
Case Report
Case reports
Immunotherapy
Irradiation
Kidney cancer
Metastasis
metastatic renal cell carcinoma
Monoclonal antibodies
nivolumab
radiation
Radiation dosage
Radiation therapy
Targeted cancer therapy
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Summary:Radiation therapy is considered an optimal partner for immunotherapies. Several pre-clinical studies have demonstrated that regression of distant metastases, at remote non-irradiated sites of the body, termed the “abscopal effect”, can be achieved by an appropriate timing and combination of radiation with immunotherapy. However, nearly all pre-clinical and clinical studies evaluating a combination of radiation and immunotherapies have used external beam radiation therapy. We present in this case report, the abscopal effect observed in a 30-year-old Japanese woman with metastatic renal cell carcinoma after the treatment with high-dose-rate interstitial brachytherapy combined with nivolumab. This is the first published report demonstrating an abscopal effect following brachytherapy for human malignancy. Our case indicates that immuno-oncology effects are not limited to external beam irradiation regimens as they can also be attained by brachytherapy.
ISSN:1689-832X
2081-2841
DOI:10.5114/jcb.2019.89365