Risk stratification for nasopharyngeal carcinoma: a real-world study based on locoregional extension patterns and Epstein-Barr virus DNA load

Aim: The present study aimed to evaluate the combined value of locoregional extension patterns (LEPs) and circulating cell-free Epstein–Barr virus (cf EBV) DNA for risk stratification of locoregionally advanced nasopharyngeal carcinoma (LA-NPC) to better guide therapeutic strategies. Methods: A tota...

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Bibliographic Details
Published in:Therapeutic advances in medical oncology 2020, Vol.12, p.1758835920932052-1758835920932052
Main Authors: Zhang, Lu-Lu, Huang, Meng-Yao, Fei-Xu, Wang, Ke-Xin, Song, Di, Wang, Ting, Sun, Li-Yue, Shao, Jian-Yong
Format: Article
Language:English
Subjects:
Chemoradiotherapy
Chemotherapy
Deoxyribonucleic acid
DNA
Epstein-Barr virus
Medical prognosis
Metastases
Nasopharyngeal carcinoma
Original Research
Throat cancer
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Summary:Aim: The present study aimed to evaluate the combined value of locoregional extension patterns (LEPs) and circulating cell-free Epstein–Barr virus (cf EBV) DNA for risk stratification of locoregionally advanced nasopharyngeal carcinoma (LA-NPC) to better guide therapeutic strategies. Methods: A total of 7227 cases of LA-NPC were reviewed retrospectively and classified into six groups according to their LEP (ascending, descending, or mixed type) and pre-treatment cf EBV-DNA load (⩾ versus
ISSN:1758-8359
1758-8340
1758-8359
DOI:10.1177/1758835920932052