Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex

• Published in: Arthritis research & therapy 2018-12, Vol.20 (1), p.284-284, Article 284
• Main Authors: Law, Lucy, Beckman Rehnman, Jeanette, Deminger, Anna, Klingberg, Eva, Jacobsson, Lennart T H, Forsblad-d'Elia, Helena
• Format: Article
• Language: English
• Subjects: Adult; Aged; Ankylosing spondylitis; Arthritis; Cancer; Cohort Studies; Cross-Sectional Studies; Cross-sectional study; Development and progression; Diabetes; Disease; Disease activity; Disease tivity; Fatigue; Female; Health aspects; Health Status; Health-related quality of life; Humans; Influence; Logistic Models; Male; Market shares; Medical outcome survey short form-36; Mental health; Middle Aged; mobility; Multivariate Analysis; Observational studies; Observational study; outcomes; pain; Patients; Population; Public health; Quality of Life; Questionnaires; Regression analysis; Reumatologi och inflammation; Rheumatology; Rheumatology and Autoimmunity; Sex differences (Biology); Sexes; sf-36; Spine - physiopathology; Spondylitis, Ankylosing - diagnosis; Spondylitis, Ankylosing - physiopathology; spondyloarthritis; Surveys and Questionnaires; Sweden; validity
• ISSN: 1478-6362; 1478-6354; 1478-6362
• DOI: 10.1186/s13075-018-1784-8

Ankylosing spondylitis (AS) begins early in life and often leads to reduced physical function, but less is known about the impacts it has on health-related quality of life (HRQoL). The aims of this study were to assess HRQoL using the Short Form-36 (SF-36) in a cohort of patients with AS compared with controls and to examine associations between SF-36 scores and spinal radiographic changes, physical function, disease activity and demographic data overall and stratified by sex. A cohort of patients with AS from Western Sweden were assessed using the Modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with spinal radiographs, clinical examination and questionnaires, including the Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score-C-reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Patient Global (BASG) and SF-36. Each patient's SF-36 results were compared with those of five age-matched and sex-matched persons (n = 1055) from the SF-36 Swedish normative population database. Associations between SF-36 physical component summary (PCS) and mental component summary (MCS) scores and disease-related and demographic factors were investigated using univariate and multivariable ogistic regression analyses with PCS and MCS below/above their respective median values as dependent variables. A total of 210 patients, age (median, IQR) 49.0 (21.2) years, symptom duration 24.0 (21.0) years, men 57.6% and HLAB27 87.1% were included. Patients with AS scored significantly lower (p