Resolvins and aliamides: lipid autacoids in ophthalmology - what promise do they hold?

Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2016-01, Vol.10, p.3133-3141
Main Authors: Hesselink, Jan M Keppel, Chiosi, Flavia, Costagliola, Ciro
Format: Article
Language:English
Subjects:
aliamides
Angiogenesis
autacoids
Autacoids - administration & dosage
Autacoids - chemistry
Autacoids - therapeutic use
Cell adhesion & migration
Cornea
dry eye
Dry Eye Syndromes - drug therapy
Fatty acids
Health aspects
Humans
Immune response
Immune system
Inflammation
Innovations
Lipids
Medicine
Metabolites
Ophthalmology
Palmitoylethanolamide
Pharmaceutical industry
Physiology
resolvins
Review
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Summary:Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives - RX-10045.
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S112389