Diagnostic Value of Cognitive-Registration Multiparametric Magnetic Resonance Guided Biopsy for the Detection of Prostate Cancer after Initial Negative Biopsy

The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017...

Full description

Saved in:
Bibliographic Details
Published in:Acta clinica Croatica (Tisak) 2018-10, Vol.57 (Suppl 1), p.40-45
Main Authors: Tomašković, Igor, Pezelj, Ivan, Bolanča Čulo, Karolina, Novosel, Luka, Nikles, Sven, Tomić, Miroslav, Reljić, Ante, Katušić, Josip, Knežević, Matej, Pirša, Matea, Kruslin, Božo, Ulamec, Monika, Ružić, Boris
Format: Article
Language:English
Subjects:
Biopsy
Humans
Image-Guided Biopsy
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Multiparametric magnetic resonance
Prospective Studies
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this prospective clinical study was to determine the detection rate of prostate cancers by multiparametric magnetic resonance and transrectal ultrasound (mpMRI-TRUS) cognitive fusion biopsies in patients with a previously negative TRUS-guided biopsy. Between 1 October 2016 and 1 July 2017, in 101 consecutive patients with elevated antigen (PSA) and/or positive digital rectal examination and after a negative first TRUS biopsy, a second, repeated prostate biopsy was performed. In 24 patients, cognitive fusion mpMRI-TRUS biopsy of the prostate with 8-10 system cores and 1-3 target biopsies was performed, in line with the European Association of Urology guidelines. In 77 patients, only a classic, repeated TRUS guided biopsy was performed. In patients with mpMRI, the detection rate according to PIRADS-v2 reporting system was: PIRADS 1, n = 0; PIRADS 2, n = 0; PIRADS 3, n = 0; PIRADS 4, n = 6/8 (75%); and PIRADS 5, n = 2/3 (67%). In the group of patients with MR-TRUS cognitive fusion biopsy, the prostate cancer detection rate was 8/24 (33%), while in the control group the detection rate was 12/77 (16%), which was statistically significant (t test, p = 0.037, CI 95% is 0.01 to 0.37). Patients with PIRADS ≤ 3 (54%) could have avoided the biopsy.
ISSN:0353-9466
1333-9451
DOI:10.20471/acc.2018.57.s1.05