Does neoadjuvant rectal score predict treatment outcomes better than the all grading systems used in neoadjuvantly treated rectal cancer?

/Objective: To compare the prognostic value of the yield pathologic (yp) stage, used 4 tumor regression grading (TRG) systems, and neoadjuvant rectal score(NARS) in patients with locally advanced rectal cancer (LARC) who received long-term neoadjuvant chemoradiotherapy (nCRT). Between 2005 and 2017,...

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Bibliographic Details
Published in:Asian journal of surgery 2023-10, Vol.46 (10), p.4378-4384
Main Authors: Sert, Fatma, Ozturk, Meltem, Yalman, Deniz, Ozkok, Serdar
Format: Article
Language:English
Subjects:
Neoadjuvant treatment neoadjuvant rectal score
Rectal cancer
Tumor regression grading
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Summary:/Objective: To compare the prognostic value of the yield pathologic (yp) stage, used 4 tumor regression grading (TRG) systems, and neoadjuvant rectal score(NARS) in patients with locally advanced rectal cancer (LARC) who received long-term neoadjuvant chemoradiotherapy (nCRT). Between 2005 and 2017, we included 302 patients with LARC who treated with nCRT. Postoperative pathological responses were graded by using Dworak, American Joint Committee on Cancer, Mandart, Memorial Sloan Kettering Cancer Center, grading systems and NARS([5ypN-3(kT-pT)+12]2/9,61) calculations. Their results were compared in terms of treatment outcomes. The median follow-up time was 51 months (range 5–136). There was a significant relation between cT stage and the response in used grading systems(p 
ISSN:1015-9584
DOI:10.1016/j.asjsur.2022.10.010