Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

• Published in: Cells (Basel, Switzerland) Switzerland), 2022-09, Vol.11 (18), p.2792
• Main Authors: Ahuja, Anami, Tyagi, Pankaj Kumar, Kumar, Manoj, Sharma, Naveen, Prakash, Suraj, Radha, Chandran, Deepak, Dhumal, Sangram, Rais, Nadeem, Singh, Surinder, Dey, Abhijit, Senapathy, Marisennayya, Saleena, Lejaniya Abdul Kalam, Shanavas, Arjun, Mohankumar, Pran, Rajalingam, Sureshkumar, Murugesan, Yasodha, Vishvanathan, Marthandan, Sathyaseelan, Sangeetha Kizhakkumkara, Viswanathan, Sabareeshwari, Kumar, Keerthana Krishna, Natta, Suman, Mekhemar, Mohamed
• Format: Article
• Language: English
• Subjects: Adipocytes; Age groups; Antioxidants; Apoptosis; Autografts; Bioactive compounds; Bone growth; Bone marrow; Bone Marrow Cells; Cell growth; Cell proliferation; Cell research; Clinical trials; Connective tissue; dental; Dental pulp; Diabetic neuropathy; Hypoxia; Inflammatory bowel disease; Ligaments; Lupus; mesenchymal cells; Mesenchymal Stem Cells - metabolism; Mesenchyme; Mucosa; Oral cavity; oral stem cells; osteogenic proliferation; Osteoporosis; Oxidative stress; Periodontal Ligament; Physiological aspects; Plant extracts; Plant Extracts - metabolism; Pluripotency; Regeneration; Regeneration (Biology); Regenerative medicine; Review; Senescence; Soft tissues; Spinal cord injuries; Stem Cells; Teeth; Telomerase; Tissue engineering
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells11182792

Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.