Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties

•Chemical fingerprint and several health promoting effects were assessed for the first time for Morina persica.•M. persica represents a rich source of chemopreventive agents.•Antiproliferative and antimutagenic effects were characterized.•Enzyme inhibitory effects were further assessed by molecular...

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Bibliographic Details
Published in:Journal of functional foods 2016-08, Vol.25, p.94-109
Main Authors: Mocan, Andrei, Zengin, Gokhan, Uysal, Ahmet, Gunes, Erdogan, Mollica, Adriano, Degirmenci, Nurdan Sena, Alpsoy, Lokman, Aktumsek, Abdurrahman
Format: Article
Language:English
Subjects:
Cytotoxic
Functional ingredients
Morina persica
Natural agents
Rutin
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Summary:•Chemical fingerprint and several health promoting effects were assessed for the first time for Morina persica.•M. persica represents a rich source of chemopreventive agents.•Antiproliferative and antimutagenic effects were characterized.•Enzyme inhibitory effects were further assessed by molecular docking with rutin as ligand.•M. persica could be considered as a strong candidate for new functional food ingredients. Morina persica L. has weak rosy smell flowers that together with aerial parts are infused or decocted and used as a functional tea. It is a representative of the Anatolian traditional medicine and is used for the treatment of cold. Biological and chemical fingerprints of different extracts (methanolic, acetone and water) of M. persica were investigated. Antioxidant, enzyme inhibitory, antimicrobial, cytotoxic and mutagenic/antimutagenic effects were evaluated for biological profiling. Rutin, chlorogenic and rosmarinic acids were detected as dominant compounds. Generally, the methanolic and acetone extracts had strong antioxidant, enzyme inhibitory, antimicrobial and antimutagenic effects. Additionally, all extracts showed remarkable inhibitory effects on HeLa cells at 100 µg/mL. Furthermore, possible interactions between rutin, the dominant phenolic compound in M. persica and the tested enzymes were assessed by molecular docking. Results indicate that M. persica could be considered as a natural source of high-valued functional ingredients for further use in healthful formulations.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2016.05.010