Recent Microfluidic Innovations for Sperm Sorting

Sperm selection is a clinical need for guided fertilization in men with low-quality semen. In this regard, microfluidics can provide an enabling platform for the precise manipulation and separation of high-quality sperm cells through applying various stimuli, including chemical agents, mechanical fo...

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Bibliographic Details
Published in:Chemosensors 2021-06, Vol.9 (6), p.126
Main Authors: Khodamoradi, Maedeh, Rafizadeh Tafti, Saeed, Mousavi Shaegh, Seyed Ali, Aflatoonian, Behrouz, Azimzadeh, Mostafa, Khashayar, Patricia
Format: Article
Language:English
Subjects:
Behavior
Cell division
Design
Embryos
Fertility
Gametocytes
In vitro fertilization
Infertility
lab-on-a-chip
Microfluidics
Morphology
Motility
Oocytes
Reagents
Reproductive technologies
Semen
Sperm
sperm sorting
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Summary:Sperm selection is a clinical need for guided fertilization in men with low-quality semen. In this regard, microfluidics can provide an enabling platform for the precise manipulation and separation of high-quality sperm cells through applying various stimuli, including chemical agents, mechanical forces, and thermal gradients. In addition, microfluidic platforms can help to guide sperms and oocytes for controlled in vitro fertilization or sperm sorting using both passive and active methods. Herein, we present a detailed review of the use of various microfluidic methods for sorting and categorizing sperms for different applications. The advantages and disadvantages of each method are further discussed and future perspectives in the field are given.
ISSN:2227-9040
2227-9040
DOI:10.3390/chemosensors9060126