Associations of long-term exposure to traffic-related air pollution with risk of valvular heart disease based on a cross-sectional study

• Published in: Ecotoxicology and environmental safety 2021-02, Vol.209, p.111753, Article 111753
• Main Authors: Pang, Yaxian, Liu, Shipeng, Yan, Lina, Wang, Qian, Li, Lipeng, Chu, Chen, Ning, Jie, Zhang, Boyuan, Wang, Xueliang, Ma, Shitao, Su, Dong, Zhang, Rong, Niu, Yujie
• Format: Article
• Language: English
• Subjects: Adult; Air Pollution - statistics & numerical data; Aortic regurgitation (AR); Cross-Sectional Studies; Echocardiography; Environmental Exposure - statistics & numerical data; Female; Heart Valve Diseases - epidemiology; Humans; Logistic Models; Male; Middle Aged; Mitral regurgitation (MR); Prevalence; Residential proximity; Traffic-related air pollution; Tricuspid regurgitation (TR); Valvular Heart Disease (VHD); Vehicle Emissions - toxicity
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2020.111753

Emerging evidence demonstrated that traffic-related air pollution induced adverse effects on cardiovascular system. We designed a population-based cross-sectional study to explore the association between residential proximity to major roadways, traffic density and the prevalence of valvular heart disease (VHD). A total of 34040 subjects from a Rural Health Project between 2013 and 2018 were collected. According to the inclusion and exclusion criteria, 4158 participants were enrolled in the final analysis. And we calculated the subjects’ proximity to major roadways and collected the traffic density on the major roadways. Transthoracic echocardiography (TTE) was performed to diagnose the VHD, according to the current AHA/ACC (the American Heart Association and the American College of Cardiology) guidelines. Differences between groups were examined by the one-way ANOVAs for continuous variables and the chi-square tests for categorical variables. A logistic regression models were used to assess the associations. The stratified analysis by age and sex were conducted to further analyze the association. The restricted cubic spline analysis was performed to further evaluate the association between road way distance and VHD. Bonferroni test was used to adjust the significance level. The subjects closer to the major roads had the higher risk of tricuspid regurgitation (TR) (odds risk, OR = 1.519, 95% confidence intervals, 95%CI: 1.058-2.181), especially in female. The risk of VHD was positive (high traffic density VS low traffic density, OR = 1.799, 95%CI: 1.221-2.651), especially in female. In addition, the high traffic density was associated with the risk of mitral regurgitation (MR) (OR = 1.758, 95%CI: 1.085-2.848). The restricted cubic spline analysis found a threshold distance of about 300 m, where had the lowest risk of VHD, aortic regurgitation (AR), MR, TR. Our results found a positive association between traffic-related air pollution and VHD especially in female. [Display omitted] •Living closer to the major roads increased the risk of tricuspid regurgitation.•High traffic density was more positively associated with mitral regurgitation.•The threshold distance for traffic-related air pollution buffer was confirmed.•The female were susceptible to the traffic-related air pollution.