Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively all...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-09, Vol.20 (19), p.4738
Main Authors: Yuan, Yiqiong, Liu, Qibing, Zhao, Fuqiang, Cao, Jun, Shen, Xuanri, Li, Chuan
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Body weight
Cholesterol
Cytokines
Diet
Diet, High-Fat - adverse effects
Disease
Disease Models, Animal
Drug dosages
Fatty Acids, Volatile - metabolism
Gastrointestinal Microbiome
Glucose
gut microbiota
High fat diet
Holothuria - chemistry
Holothuria leucospilota
Hormones
Hormones - metabolism
Hyperlipidemia
Hyperlipidemias - drug therapy
Hyperlipidemias - etiology
Hyperlipidemias - metabolism
Inflammation
Inflammation Mediators
Insulin resistance
Interleukin 12
Interleukin 6
Intestinal microflora
Lipid metabolism
Lipid Metabolism - drug effects
Lipids
Lipids - blood
Lipogenesis
Lipoproteins
Liver
Liver - metabolism
Liver - pathology
Metabolic disorders
Microbiota
Models, Biological
mRNA
Oral administration
Polysaccharides
Polysaccharides - chemistry
Polysaccharides - pharmacology
Rats
short-chain fatty acids
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-α, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20194738