Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients

• Published in: Nefrología 2019-03, Vol.39 (2), p.184-191
• Main Authors: Rodríguez-Sánchez, Elena, Navarro-García, José Alberto, Aceves-Ripoll, Jennifer, Álvarez-Llamas, Gloria, Segura, Julián, Barderas, María G., Ruilope, Luis Miguel, Ruiz-Hurtado, Gema
• Format: Article
• Language: English
• ISSN: 2013-2514
• DOI: 10.1016/j.nefroe.2019.03.006

Background and objective: Matrix metalloproteinases (MMPs) are involved in deleterious tissue remodelling associated with target organ damage in renal disease. The aim of this study was to study the association between renal dysfunction and activity of the inflammatory metalloproteinase MMP-9 in hypertensive patients with mild-moderate chronic kidney disease (CKD). Material and methods: Plasmatic active MMP-9, total MMP-9, tissue inhibitor of MMP-9 (TIMP-1), MMP-9/TIMP-1 ratio and MMP-9-TIMP-1 interaction were analysed in 37 hypertensive patients distributed by estimated glomerular filtration rate (eGFR) in 3 groups: >90, 90–60 and 60–30 mL/min/1.73 m2. Results: Total MMP-9 was not different as eGFR declines. TIMP-1 was significantly increased in hypertensive patients with eGFR 60–30 mL/min/1.73 m2 (p 90 mL/min/1.73 m2). This relates to the significant decrease in the interaction between MMP-9-TIMP-1 observed in patients with eGFR 60–30 mL/min/1.73 m2 (p 90 mL/min/1.73 m2). Despite the systemic elevation of TIMP-1, active MMP-9 was significantly increased in hypertensive patients with eGFR 60–30 mL/min/1.73 m2 (p  90, 90–60 y 60–30 mL/min/1,73 m2. Resultados: La MMP-9 total no fue diferente con respecto a la disminución en la TFGe. TIMP-1 estaba significativamente incrementado en los pacientes hipert