Membrane Carriers and Transporters in Kidney Physiology and Disease

The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as xenobiotics (drugs and toxins) with subsequent...

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Bibliographic Details
Published in:Biomedicines 2021-04, Vol.9 (4), p.426
Main Authors: Drozdzik, Marek, Drozdzik, Maria, Oswald, Stefan
Format: Article
Language:English
Subjects:
ABC transporters
Adenosine triphosphate
Bile
Drug administration
Drug interactions
drug transporters
kidney
Kidney diseases
kidney pathology
Kidneys
Membranes
Oats
Pathophysiology
Pharmacokinetics
Proteins
Renal function
Review
Sodium
Solutes
Xenobiotics
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Summary:The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as xenobiotics (drugs and toxins) with subsequent clinical consequences. The renal carriers and transporters are also targets of drugs used in clinical practice, and intentional drug-drug interactions in the kidney are produced to increase therapeutic efficacy. The understanding of membrane carriers and transporters function in chronic kidney disease is important not only to better characterize drug pharmacokinetics, drug actions in the kidney, or drug-drug interactions but also to define the organ pathophysiology.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9040426