The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor

Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal com...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2000-07, Vol.33 (7), p.815-822
Main Authors: Vido, A A, Cavalcanti, T C, Guimarães, F, Vieira-Matos, A N, Rettori, O
Format: Article
Language:English
Subjects:
Analysis of Variance
Anemia, Hemolytic - blood
Anemia, Hemolytic - etiology
Animals
Anorexia - etiology
BIOLOGY
cancer anemia
Carcinoma 256, Walker - blood
Carcinoma 256, Walker - chemically induced
Chronic Disease
Disease Models, Animal
Hemoglobins - metabolism
hemolytic component
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Neoplasm Transplantation
Osmotic Fragility
Rats
Rats, Wistar
systemic effects
Time Factors
Walker 256 tumor
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Summary:Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells). The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 +/- 0.02 to 8.7 +/- 0.06 from days 7 to 11 ( approximately 5 times the physiologically normal rate in rats) in the absence of bleeding. The development of anemia was correlated (r2 = 0.86) with the development of other systemic effects such as anorexia. There was a significant decrease in the osmotic fragility of circulating erythrocytes: the NaCl concentration causing 50% lysis was reduced from 4.52 +/- 0.06 to 4.10 +/- 0.01 (P
ISSN:0100-879X
1414-431X
0100-879X
0034-7310
DOI:10.1590/S0100-879X2000000700012